Seiji Watanabe

About

Work

Faculty of Medicine, Shimane University
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Associate Professor

Japan

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Research Institute of Environmental Medicine, Nagoya University
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Lecturer

Japan

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Research Institute of Environmental Medicine, Nagoya University
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Assistant Professor

Japan

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Research Institute of Environmental Medicine, Nagoya University
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Researcher

Japan

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RIKEN Brain Science Institute
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Researcher

Japan

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Japan Society for the Promotion of Science
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JSPS Research Fellow

Japan

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Education

Graduate School of Arts & Sciences, University of Tokyo
Japan

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Ph.D.

Publications

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

Published by

BioEssays

Summary

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ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice.

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Acta neuropathologica communications

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Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation

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Cell Death & Disease

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Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

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Scientific Reports

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Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease

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Journal of Neuroinflammation

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Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice

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iScience

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Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS

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Proceedings of the National Academy of Sciences

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Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis

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Science Advances

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Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.

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The Journal of biological chemistry

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Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.

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Neurobiology of disease

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Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.

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FASEB journal : official publication of the Federation of American Societies for Experimental Biology

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Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis

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The FASEB Journal

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Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

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Acta neuropathologica communications

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Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43.

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Cell death & disease

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Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.

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EBioMedicine

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ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration.

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Molecular brain

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Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.

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Acta neuropathologica communications

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A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis.

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Biochimica et biophysica acta

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Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

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Cell death and differentiation

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Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice.

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Journal of neurochemistry

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Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth

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FEBS Open Bio

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Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

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Molecular Neurodegeneration

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TDP-43 accelerates age-dependent degeneration of interneurons

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Scientific Reports

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Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

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Neurobiology of Disease

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Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS

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EMBO Molecular Medicine

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Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

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Acta neuropathologica communications

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Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

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Cell Reports

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Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

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Cell Death and Disease

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Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

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Proceedings of the National Academy of Sciences of the United States of America

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SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

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Molecular Brain

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Crucial roles of Glu60 in human neuroglobin as a guanine nucleotide dissociation inhibitor and neuroprotective agent

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PLoS ONE

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Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells

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Biochimica et Biophysica Acta - Proteins and Proteomics

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Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection

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Journal of Biological Chemistry

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Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity

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PLoS ONE

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Species-specific functional evolution of neuroglobin

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Marine Genomics

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Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin

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FEBS Letters

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Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity

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Biochemical and Biophysical Research Communications

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Zebrafish neuroglobin is a cell-membrane-penetrating globin

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Biochemistry

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