Seiji Watanabe

Work

Faculty of Medicine, Shimane University

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Associate Professor

Japan

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Research Institute of Environmental Medicine, Nagoya University

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Lecturer

Japan

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Research Institute of Environmental Medicine, Nagoya University

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Assistant Professor

Japan

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Research Institute of Environmental Medicine, Nagoya University

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Researcher

Japan

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RIKEN Brain Science Institute

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Researcher

Japan

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Japan Society for the Promotion of Science

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JSPS Research Fellow

Japan

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Education

Graduate School of Arts & Sciences, University of Tokyo

Japan
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Ph.D.

Publications

Mitochondria and Endoplasmic Reticulum Contact Site as a Regulator of Proteostatic Stress Responses in Neurodegenerative Diseases

BioEssays

journal-article

ALS-linked mutant TDP-43 in oligodendrocytes induces oligodendrocyte damage and exacerbates motor dysfunction in mice.

Acta neuropathologica communications

journal-article

Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation

Cell Death & Disease

journal-article

Ebselen analogues delay disease onset and its course in fALS by on-target SOD-1 engagement

Scientific Reports

journal-article

Dimethyl fumarate improves cognitive impairment and neuroinflammation in mice with Alzheimer’s disease

Journal of Neuroinflammation

journal-article

Genetic background variation impacts microglial heterogeneity and disease progression in amyotrophic lateral sclerosis model mice

iScience

journal-article

Mitochondria-associated membrane collapse impairs TBK1-mediated proteostatic stress response in ALS

Proceedings of the National Academy of Sciences

journal-article

Monomerization of TDP-43 is a key determinant for inducing TDP-43 pathology in amyotrophic lateral sclerosis

Science Advances

journal-article

Intrinsic structural vulnerability in the hydrophobic core induces species-specific aggregation of canine SOD1 with degenerative myelopathy-linked E40K mutation.

The Journal of biological chemistry

journal-article

Sigma-1 receptor maintains ATAD3A as a monomer to inhibit mitochondrial fragmentation at the mitochondria-associated membrane in amyotrophic lateral sclerosis.

Neurobiology of disease

journal-article

Novel reporters of mitochondria-associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

journal-article

Novel reporters of mitochondria‐associated membranes (MAM), MAMtrackers, demonstrate MAM disruption as a common pathological feature in amyotrophic lateral sclerosis

The FASEB Journal

journal-article

Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease.

Acta neuropathologica communications

journal-article

Aggresome formation and liquid-liquid phase separation independently induce cytoplasmic aggregation of TAR DNA-binding protein 43.

Cell death & disease

journal-article

Novel Selenium-based compounds with therapeutic potential for SOD1-linked amyotrophic lateral sclerosis.

EBioMedicine

journal-article

ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration.

Molecular brain

journal-article

Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.

Acta neuropathologica communications

journal-article

A copper-deficient form of mutant cu/Zn-superoxide dismutase as an early pathological species in amyotrophic lateral sclerosis.

Biochimica et biophysica acta

journal-article

Innate immune adaptor TRIF deficiency accelerates disease progression of ALS mice with accumulation of aberrantly activated astrocytes.

Cell death and differentiation

journal-article

Intracerebroventricular administration of Cystatin C ameliorates disease in SOD1-linked amyotrophic lateral sclerosis mice.

Journal of neurochemistry

journal-article

Chimeric ZHHH neuroglobin acts as a cell membrane-penetrating inducer of neurite outgrowth

FEBS Open Bio

journal-article

Immunochemical characterization on pathological oligomers of mutant Cu/Zn-superoxide dismutase in amyotrophic lateral sclerosis

Molecular Neurodegeneration

journal-article

TDP-43 accelerates age-dependent degeneration of interneurons

Scientific Reports

journal-article

Mahogunin ring finger 1 confers cytoprotection against mutant SOD1 aggresomes and is defective in an ALS mouse model

Neurobiology of Disease

journal-article

Mitochondria-associated membrane collapse is a common pathomechanism in SIGMAR1- and SOD1-linked ALS

EMBO Molecular Medicine

journal-article

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons

Acta neuropathologica communications

journal-article

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

Cell Reports

journal-article

Cystatin C protects neuronal cells against mutant copper-zinc superoxide dismutase-mediated toxicity

Cell Death and Disease

journal-article

Disease causing mutants of TDP-43 nucleic acid binding domains are resistant to aggregation and have increased stability and half-life

Proceedings of the National Academy of Sciences of the United States of America

journal-article

SIRT1 overexpression ameliorates a mouse model of SOD1-linked amyotrophic lateral sclerosis via HSF1/HSP70i chaperone system

Molecular Brain

journal-article

Crucial roles of Glu60 in human neuroglobin as a guanine nucleotide dissociation inhibitor and neuroprotective agent

PLoS ONE

journal-article

Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells

Biochimica et Biophysica Acta - Proteins and Proteomics

journal-article

Human neuroglobin functions as an oxidative stress-responsive sensor for neuroprotection

Journal of Biological Chemistry

journal-article

Module M1 of zebrafish neuroglobin acts as a structural and functional protein building block for a cell-membrane-penetrating activity

PLoS ONE

journal-article

Species-specific functional evolution of neuroglobin

Marine Genomics

journal-article

Identification of residues critical for the cell-membrane-penetrating activity of zebrafish neuroglobin

FEBS Letters

journal-article

Neuroprotective function of human neuroglobin is correlated with its guanine nucleotide dissociation inhibitor activity

Biochemical and Biophysical Research Communications

journal-article

Zebrafish neuroglobin is a cell-membrane-penetrating globin

Biochemistry

journal-article